Fourth Round : 2021 - 2022

26 October 2021 - 19:45
Queens Park Rangers  -  Sunderland
26 October 2021 - 19:45
Arsenal  -  Leeds United
26 October 2021 - 19:45
Chelsea  -  Southampton
27 October 2021 - 19:45
Burnley  -  Tottenham Hotspur
27 October 2021 - 19:45
Leicester City  -  Brighton & Hove Albion
27 October 2021 - 19:45
West Ham United  -  Manchester City
27 October 2021 - 19:45
Preston North End  -  Liverpool
27 October 2021 - 19:45
Stoke City  -  Brentford